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Article

Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).

Blood - 15 Jun 2005

Eissmann Philipp, Beauchamp Lisa, Wooters Joe, Tilton John C, Long Eric O, Watzl Carsten

Abstract excerpt

Triggering of 2B4 (CD244) can induce natural killer (NK)-cell activation, costimulation, or even inhibition of NK-cell activity. Here, we investigate the molecular basis for the different signals generated by 2B4. We show that the first immunoreceptor tyrosine-based switch motif (ITSM) within the...

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Identifiers

PMID: 15713798
DOI: 10.1182/blood-2004-09-3796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-15713798-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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