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Article

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.

Immunological reviews - 1 Feb 2005

Nichols Kim E, Ma Cindy S, Cannons Jennifer L, Schwartzberg Pamela L, Tangye Stuart G

Abstract excerpt

X-linked lymphoproliferative disease (XLP) is an inherited immune defect caused by mutations in the Src homology 2 domain-containing gene 1A, which encodes the adapter protein, signaling lymphocytic activation molecule (SLAM)-associated protein (SAP). SAP is expressed in T cells, natural killer (NK) cells, and NKT cells, where it binds to the cytoplasmic domain of the surface receptor SLAM (CD150) and the related...

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Identifiers

PMID: 15661030
DOI: 10.1111/j.0105-2896.2005.00230.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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