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Article

Signaling lymphocytic activation molecule-associated protein controls NKT cell functions.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2005

Chung Brian, Aoukaty Ala, Dutz Jan, Terhorst Cox, Tan Rusung

Abstract excerpt

X-linked lymphoproliferative disease (XLP) is a fatal immunological disorder that typically manifests following EBV infection. XLP patients exhibit a number of immune defects including abnormal T, B, and NK lymphocyte function. These defects have been attributed to mutations of Src homology 2 domain-containing gene 1A (SH2D1A), the gene encoding signaling lymphocytic activation molecule-associated protein (SAP),...

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Source

Identifiers

PMID: 15749842
DOI: 10.4049/jimmunol.174.6.3153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Signaling lymphocytic activation molecule-associated protein controls NKT cell functions.PMID 15749842Read ↗

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SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.Semantic proximity Read ↗

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SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative diseaseSemantic proximity Read ↗

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