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Article

SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease

19 Jan 2004

Abstract excerpt

Cytotoxic T cells (CTLs) and natural killer cells play a major role in the immune response to Epstein-Barr virus (EBV) infection. In X-linked lymphoproliferative (XLP) disease, a severe immunodeficiency, immunodysregulatory phenomena are observed following EBV infection, suggesting that defects exist in these effector populations. The gene defective in XLP is SAP (signaling lymphocytic activation molecule...

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PMID: 14726378
DOI: 10.1182/blood-2003-09-3359

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SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative diseasePMID 14726378Read ↗

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