Article
Genotype-dependent expression of endothelial nitric oxide synthase (eNOS) and its regulatory proteins in cultured endothelial cells.
DNA and cell biology - 1 Apr 2005
Senthil Duraisamy, Raveendran Muthuswamy, Shen Ying H, Utama Budi, Dudley Donald, Wang Jian, Wang Xing Li
Abstract excerpt
DNA polymorphisms in endothelial nitric oxide synthase (eNOS) gene have been shown to be associated with constitutive eNOS expression and coronary artery disease (CAD). In the present study we explored the hypothesis whether genotype-dependent effects can be maintained in vitro during replication, or the effect is conditional on in vivo biological environments. Human umbilical vein endothelial cells (HUVEC) were...
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