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Influence of endothelial nitric oxide synthase haplotypes on nitric oxide and peroxynitrite productions.

Bioelectrochemistry (Amsterdam, Netherlands) - 1 Feb 2025

Alsulami Seham O, Malinski Tadeusz, Dewald Howard D

Abstract excerpt

The impact of four clinically significant genetic variants of endothelial nitric oxide synthase (eNOS) polymorphisms on the concentrations of nitric oxide [NO] and peroxynitrite [ONOO-] has been given scant consideration. This study utilized a [NO]/[ONOO-] ratio to determine the extent of endothelial dysfunction caused by these variations in the eNOS gene. The single nucleotide polymorphisms (T-786C, C-665T, and...

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PMID: 39426051
DOI: 10.1016/j.bioelechem.2024.108837

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