Article
Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity.
FEBS letters - 7 Apr 2000
Wang X L, Sim A S, Wang M X, Murrell G A, Trudinger B, Wang J
Abstract excerpt
We explored the interactive effects of endothelial nitric oxide synthase (eNOS) genotypes and cigarette smoking on protein levels and enzyme activity in 33 postpartum placentas. Whilst the eNOS protein levels were lower in the rare allele (0.48+/-0.11, n=9 vs. 1. 05+/-0.10, n=24, P<0.01), the eNOS enzyme activity was about 7-fold higher in the rare allele (4556.2+/-255.4 vs. 621.8+/-180.5 cpm/mg/min, P<0.01)....
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