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Article

Dynamic mechanism for the serpin loop insertion as revealed by quantitative kinetics.

Journal of molecular biology - 29 Apr 2005

Takahashi Nobuyuki, Terakado Kanako, Nakamura Genichi, Soekmadji Carolina, Masuoka Toshio, Yamasaki Masayuki, Hirose Masaaki

Abstract excerpt

The serpin conformational change by insertion of the reactive center loop into beta-sheet A plays a central role in multiple physiological consequences such as serine proteinase inhibition, latency and serpinopathic polymerization. To study the dynamic mechanism for the loop insertion, a novel kinetic method was established utilizing the ovalbumin mutant R339T/A352R; the loop insertion progressed after the...

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Identifiers

PMID: 15811377
DOI: 10.1016/j.jmb.2005.02.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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