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Article

Conformational changes in serpins and the mechanism of alpha 1-antitrypsin deficiency.

American journal of respiratory and critical care medicine - 1 Dec 1994

Carrell R W, Whisstock J, Lomas D A

Abstract excerpt

alpha 1-Antitrypsin is a member of the serine proteinase inhibitor, serpin, family of protease inhibitors, which have their reactive centers situated on a mobile peptide loop. This reactive loop can adopt varied conformations and perturbations of molecular structure to allow the pathological linking of the loop of one molecule to a beta-pleated sheet of another. This linkage has been shown to be the cause of the...

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Identifiers

PMID: 7952655
DOI: 10.1164/ajrccm/150.6_Pt_2.S171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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