Conformational changes in serpins and the mechanism of alpha 1-antitrypsin deficiency.

doi:10.1164/ajrccm/150.6_Pt_2.S171

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Article

Conformational changes in serpins and the mechanism of alpha 1-antitrypsin deficiency.

American journal of respiratory and critical care medicine - 1 Dec 1994

Carrell R W, Whisstock J, Lomas D A

Abstract excerpt

alpha 1-Antitrypsin is a member of the serine proteinase inhibitor, serpin, family of protease inhibitors, which have their reactive centers situated on a mobile peptide loop. This reactive loop can adopt varied conformations and perturbations of molecular structure to allow the pathological link...

Topics

Humans
Liver
Liver Diseases
Phenotype
Polymers
Protein Conformation
Serpins
alpha 1-Antitrypsin Deficiency

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