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Polymorphisms in the androgen receptor and the prostate-specific antigen genes and prostate cancer risk

4 Apr 2005

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) is an androgen-dependent disease. Polymorphic CAG and GGC microsatellites in the androgen receptor (AR) can alter transactivation of androgen-responsive genes in in vitro studies. Potentially, this may influence PCa risk. METHODS: Germline DNA samples and survey data were collected from 591 newly diagnosed PCa cases and 538 population-based controls of similar age (40-64 years),...

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PMID: 15810021
DOI: 10.1002/pros.20230

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