Article
The C/C genotype of the C957T polymorphism of the dopamine D2 receptor is associated with schizophrenia.
Schizophrenia research - 1 Feb 2005
Lawford Bruce R, Young Ross McD, Swagell Christopher D, Barnes Mark, Burton Simon C, Ward Warren K, Heslop Karen R, Shadforth Susan, van Daal Angela, Morris C Phillip
Abstract excerpt
The T allele of the human dopamine D2 receptor (DRD2) gene C957T polymorphism is associated with reduced mRNA translation and stability. This results in decreased dopamine induced DRD2 upregulation and decreased in vivo D2 dopamine binding. Conversely, the C allele of the C957T polymorphism is not associated with such changes in mRNA leading to increased DRD2 expression. PET and postmortem binding studies show...
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