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Article

PROGINS Alu sequence insertion is associated with hyperprolactinaemia but not leiomyoma susceptibility.

Clinical endocrinology - 1 Apr 2005

Hsieh Yao-Yuan, Chan Ian-Pan, Wang Hsin-I, Chang Chi-Chen, Huang Ching-Wei, Lin Chich-Sheng

Abstract excerpt

OBJECTIVE: Leiomyoma and hyperprolactinaemia are both progesterone-dependent diseases. Hormone-related genes, such as the progesterone receptor (PGR), might be involved in their pathogenesis. DESIGN AND MEASUREMENTS: Subjects were divided into three groups: (i) leiomyoma (n = 120); (ii) hyperprolactinaemia (n = 101); (iii) normal controls (n = 140). We investigated the Alu (306-bp DNA) insertion in intron G of...

Topics

Adult
Alleles
Alu Elements
Asian People
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Hyperprolactinemia
Leiomyoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Receptors, Progesterone

Taiwan

Uterine Neoplasms

Source

Identifiers

PMID: 15807882
DOI: 10.1111/j.1365-2265.2005.02251.x

Genes

PGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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PROGINS Alu sequence insertion is associated with hyperprolactinaemia but not leiomyoma susceptibility.PMID 15807882Read ↗

Molecular determination of progesterone receptor's PROGINS allele (Alu insertion) and its association with the predisposition and susceptibility to polycystic ovary syndrome (PCOS).Semantic proximity Read ↗

Association of the PROGINS PgR polymorphism with susceptibility to female reproductive cancer: A meta-analysis of 30 studies.Semantic proximity Read ↗

Effect of steroid hormone receptor gene variants PROGINS (Alu insertion) and PGR C/T (rs1042839) as a risk factor for recurrent pregnancy loss in Kashmiri population (North India).Semantic proximity Read ↗

Ovarian carcinoma-associated TaqI restriction fragment length polymorphism in intron G of the progesterone receptor gene is due to an Alu sequence insertion.Semantic proximity Read ↗

Molecular Evaluation of PROGINS Mutation in Progesterone Receptor Gene and Determination of its Frequency, Distribution Pattern and Association with Breast Cancer Susceptibility in Saudi Arabia.Semantic proximity Read ↗

Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk.Semantic proximity Read ↗

Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer.Semantic proximity Read ↗

The progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroids.Semantic proximity Read ↗

Polymorphisms of p53 promoter and susceptibility to uterine leiomyoma.Semantic proximity Read ↗

Polymorphisms of progesterone receptor and ovarian cancer risk: a systemic review and meta-analysis.Semantic proximity Read ↗

Two functionally relevant polymorphisms in the human progesterone receptor gene (+331 G/A and progins) and the predisposition for breast and/or ovarian cancer.Semantic proximity Read ↗

Association of estrogen and progesterone receptor gene polymorphisms and their respective hormones in uterine leiomyomas.Semantic proximity Read ↗

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