Article
Ovarian carcinoma-associated TaqI restriction fragment length polymorphism in intron G of the progesterone receptor gene is due to an Alu sequence insertion.
Cancer research - 1 Jul 1995
Rowe S M, Coughlan S J, McKenna N J, Garrett E, Kieback D G, Carney D N, Headon D R
Abstract excerpt
Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (approximately 300-bp) insertion that was inherited in a Mendelian...
Topics
- Alleles
- Base Sequence
- Deoxyribonucleases, Type II Site-Specific
- Female
- Humans
- Introns
- Molecular Sequence Data
- Ovarian Neoplasms
- Polymorphism, Restriction Fragment Length
- RNA Splicing