Article
Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk.
American journal of obstetrics and gynecology - 1 Dec 2008
Renner Stefan P, Strick Reiner, Fasching Peter A, Oeser Sonja, Oppelt Peter, Mueller Andreas, Beckmann Matthias W, Strissel Pamela L
Abstract excerpt
OBJECTIVE: Uterine benign leiomyomas result from proliferation of a single smooth-muscle cell and their growth is affected by steroid hormones via steroid hormone receptors. This investigation analyzed the +331G/A and the V600L single nucleotide polymorphisms in the progesterone receptor, and correlated their incidence with clinical and tumor parameters as well as disease risk. STUDY DESIGN: Peripheral blood DNA...
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