Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer.

Cancer biology & therapy - 1 Jan 2000

Matsubayashi Hiroyuki, Fukushima Noriyoshi, Sato Norihiro, Brune Kieran, Canto Marcia, Yeo Charles J, Hruban Ralph H, Kern Scott E, Goggins Michael

Abstract excerpt

Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients who carry polymorphisms in SPINK1 and CFTR are at increased risk of developing pancreatic cancer through the development of chronic pancreatitis. DNA from patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chronic Disease

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Pancreatic Neoplasms

Share to Pancreatitis

Share to Prevalence

Share to Trypsin Inhibitor, Kazal Pancreatic

Source

Identifiers

PMID: 14688470

Genes

CFTR
SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer.PMID 14688470Read ↗

Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis.Semantic proximity Read ↗

Clinical and Morphological Characteristics of Sporadic Genetically Determined Pancreatitis as Compared to Idiopathic Pancreatitis: Higher Risk of Pancreatic Cancer in CFTR VariantsSemantic proximity Read ↗

SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.Semantic proximity Read ↗

Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland.Semantic proximity Read ↗

CFTR, SPINK1, PRSS1, and CTRC mutations are not associated with pancreatic cancer in German patients.Semantic proximity Read ↗

PRSS1 intron mutations in patients with pancreatic cancer and chronic pancreatitis.Semantic proximity Read ↗

Cystic fibrosis transmembrane regulator (CFTR) DeltaF508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer. PANKRAS II Study Group.Semantic proximity Read ↗

Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls.Semantic proximity Read ↗

CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?Semantic proximity Read ↗

The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.Semantic proximity Read ↗

Hereditary Pancreatitis Related to SPINK-1 Mutation. Is There an Increased Risk of Developing Pancreatic Cancer?Semantic proximity Read ↗

N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.