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Article

N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2003

Teich Niels, Schulz Hans-Ulrich, Witt Heiko, Böhmig Michael, Keim Volker

Abstract excerpt

BACKGROUND: The SPINK1 mutation N34S is associated to chronic pancreatitis of idiopathic, alcoholic and tropic origin. Our aim was to evaluate its prevalence in patients with sporadic pancreatic cancer. METHODS: The N34S allele of SPINK1 was analyzed by melting curve analysis using fluorescence resonance energy transfer (FRET) probes and the LightCycler in 159 German patients with sporadic pancreatic cancer (83...

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Source

Identifiers

PMID: 12649567
DOI: 10.1159/000069145

Genes

SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer.PMID 12649567Read ↗

The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.Semantic proximity Read ↗

Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland.Semantic proximity Read ↗

Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States.Semantic proximity Read ↗

Meta-analysis of the impact of SPINK1 p.N34S gene variation in Caucasic patients with chronic pancreatitis. An update.Semantic proximity Read ↗

The SPINK1 N34S variant is associated with acute pancreatitis.Semantic proximity Read ↗

Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer.Semantic proximity Read ↗

The N34S mutation of the SPINK1 gene and alcoholic chronic pancreatitis.Semantic proximity Read ↗

Keratin 8 mutations are not associated with familial, sporadic and alcoholic pancreatitis in a population from the United States.Semantic proximity Read ↗

Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis.Semantic proximity Read ↗

SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.Semantic proximity Read ↗

Chronic Pancreatitis: The True Pathogenic Culprit within the SPINK1 N34S-Containing Haplotype Is No Longer at Large.Semantic proximity Read ↗

Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis.Semantic proximity Read ↗

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