Article
Germline BRCA1 mutations predispose to pancreatic adenocarcinoma.
Human genetics - 1 Oct 2008
Al-Sukhni Wigdan, Rothenmund Heidi, Borgida Ayelet Eppel, Zogopoulos George, O'Shea Anne-Marie, Pollett Aaron, Gallinger Steven
Abstract excerpt
Although the association of germline BRCA2 mutations with pancreatic adenocarcinoma is well established, the role of BRCA1 mutations is less clear. We hypothesized that the loss of heterozygosity at the BRCA1 locus occurs in pancreatic cancers of germline BRCA1 mutation carriers, acting as a "second-hit" event contributing to pancreatic tumorigenesis. Seven germline BRCA1 mutation carriers with pancreatic...
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