Article
Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function.
The Journal of biological chemistry - 3 Jun 2005
Mancl Margo E, Hu Guodong, Sangster-Guity Niquiche, Olshalsky Stacey L, Hoops Katherine, Fitzgerald-Bocarsly Patricia, Pitha Paula M, Pinder Karen, Barnes Betsy J
Abstract excerpt
Interferon regulatory factor-5 (IRF-5) is a mediator of virus-induced immune activation and type I interferon (IFN) gene regulation. In human primary plasmacytoid dendritic cells (PDC), IRF-5 is transcribed into four distinct alternatively spliced isoforms (V1, V2, V3, and V4), whereas in human primary peripheral blood mononuclear cells two additional new isoforms (V5 and V6) were identified. The IRF-5 V1, V2,...
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