Critical Role of Plasmacytoid Dendritic Cells in Regulating Gene Expression and Innate Immune Responses to Human Rhinovirus-16

Abstract excerpt

Though human rhinoviruses (HRV) are usually innocuous viruses, they can trigger serious consequences in certain individuals, especially in the setting of impaired interferon synthesis. Plasmacytoid dendritic cells (pDC) are key IFN producing cells, though we know little about the role of pDC in HRV-induced immune responses. Herein we used gene expression microarrays to examine HRV-activated peripheral blood...

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