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Article

Transgenic mouse models in carcinogenesis: interaction of c‐<i>myc</i> with transforming growth factor α and hepatocyte growth factor in hepatocarcinogenesis

1 Jul 1996

Abstract excerpt

1. Overexpression of the c-myc oncogene is associated with a variety of both human and experimental tumours, and cooperation of other oncogenes and growth factors with the myc family are critical in the evolution of the malignant phenotype. 2. Double transgenic mice bearing fusion genes consisting of mouse albumin enhancer/promoter-mouse c-myc cDNA and mouse metallothionein 1 promoter-human transforming growth...

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PMID: 8807143
DOI: 10.1046/j.1365-2125.1996.03748.x

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