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Article

Ligand-binding and signaling properties of the Ax[M1] form of Notch.

Mechanisms of development - 1 Apr 2005

Pérez Lidia, Milán Marco, Bray Sarah, Cohen Stephen M

Abstract excerpt

The Abruptex class of Notch alleles has attracted interest because they exhibit some properties that are best explained in terms of increased activity and others that are best explained in terms of reduced activity in vivo. Here, we report a comparison of the properties of Abruptex[M1] and wild-type Notch as ligand binding receptors. Abruptex[M1] showed less activity than wild-type Notch in its ability to bind...

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Identifiers

PMID: 15804562
DOI: 10.1016/j.mod.2004.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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