Article
High activity suppression of myeloid progenitor proliferation by chimeric mutants of interleukin 8 and platelet factor 4.
The Journal of biological chemistry - 6 Oct 1995
Daly T J, LaRosa G J, Dolich S, Maione T E, Cooper S, Broxmeyer H E
Abstract excerpt
The proliferation of human myeloid progenitor cells is negatively regulated in the presence of certain members of the chemokine family of molecules. This includes interleukin 8 (IL-8) and platelet factor 4 (PF4), which in combination are able to synergize, resulting in cell suppression at very lo...
Topics
- Amino Acid Sequence
- Animals
- Antigens, CD
- CHO Cells
- Cell Division
- Chemokines
- Cricetinae
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- In Vitro Techniques
- Interleukin-8
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Neutrophils
- Platelet Factor 4