Article
Adoptive transfer of T-helper cell type 1 clones attenuates an asthmatic phenotype in mice.
The European respiratory journal - 1 Apr 2005
Irifune K, Yokoyama A, Sakai K, Watanabe A, Katayama H, Ohnishi H, Hamada H, Nakajima M, Kohno N, Higaki J
Abstract excerpt
T-helper cell type 1 (Th1) cells have been postulated to have a significant role in protective immunity against allergic diseases. However, recent studies using polarised Th1 cells showed conflicting effects on both airway responsiveness and eosinophilic inflammation in a mouse asthma model. The current study explored the effects of adoptive transfer of established Th1 clones on a murine model of atopic asthma....
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