Article
CD8+ T cells in asthma: friend or foe?
Pharmacology & therapeutics - 1 Feb 2009
Betts Richard J, Kemeny D Michael
Abstract excerpt
While it is well established that CD4(+) T lymphocytes play a crucial role in the initiation, progression and persistence of asthma, the role of CD8(+) T cells is less understood. CD8(+) T cells form functionally similar subsets which exhibit similar cytokine profiles as Th1 and Th2 cells, known as Tc1 and Tc2. Evidence from animal studies suggest that CD8(+) T cells are capable of regulating IgE production...
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