Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.

Molecular biology of the cell - 1 Dec 2004

Shin Hye-Won, Morinaga Naoko, Noda Masatoshi, Nakayama Kazuhisa

Abstract excerpt

Small GTPases of the ADP-ribosylation factor (ARF) family play a key role in membrane trafficking by regulating coated vesicle formation, and guanine nucleotide exchange is essential for the ARF function. Brefeldin A blocks the ARF-triggered coat assembly by inhibiting the guanine nucleotide exchange on ARFs and causes disintegration of the Golgi complex and tubulation of endosomal membranes. BIG2 is one of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factors
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Glutamic Acid

Share to Guanine Nucleotide Exchange Factors

Share to rab GTP-Binding Proteins

Share to Serine

Share to Shiga Toxin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 15385626
DOI: 10.1091/mbc.e04-05-0388
PMCID: PMC532010

Genes

ARF1
ARF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.PMID 15385626Read ↗

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.Semantic proximity Read ↗

Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1.Semantic proximity Read ↗

Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.Semantic proximity Read ↗

Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1.Semantic proximity Read ↗

Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex.Semantic proximity Read ↗

Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.Semantic proximity Read ↗

The ARF GTPases: defining roles in membrane traffic and organelle structure.Semantic proximity Read ↗

Rab and Arf proteins in genetic diseases.Semantic proximity Read ↗

The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.Semantic proximity Read ↗

Emerging role of Cdc42-specific guanine nucleotide exchange factors as regulators of membrane trafficking in health and disease.Semantic proximity Read ↗

GGA2 and RAB13 promote activity-dependent β1-integrin recyclingSemantic proximity Read ↗

BEN3/BIG2 ARF GEF is Involved in Brefeldin A-Sensitive Trafficking at the trans-Golgi Network/Early Endosome in Arabidopsis thaliana.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.