Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.

The Journal of cell biology - 7 Jul 2003

Krauss Michael, Kinuta Masahiro, Wenk Markus R, De Camilli Pietro, Takei Kohji, Haucke Volker

Abstract excerpt

Clathrin-mediated endocytosis of synaptic vesicle membranes involves the recruitment of clathrin and AP-2 adaptor complexes to the presynaptic plasma membrane. Phosphoinositides have been implicated in nucleating coat assembly by directly binding to several endocytotic proteins including AP-2 and AP180. Here, we show that the stimulatory effect of ATP and GTPgammaS on clathrin coat recruitment is mediated at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Protein Complex 2
Share to ADP-Ribosylation Factor 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ADP-Ribosylation Factors

Share to Brefeldin A

Share to Clathrin

Share to Guanosine 5'-O-(3-Thiotriphosphate)

Share to Synaptic Membranes

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 12847086
DOI: 10.1083/jcb.200301006
PMCID: PMC2172713

Genes

ARF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.PMID 12847086Read ↗

The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.Semantic proximity Read ↗

A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis.Semantic proximity Read ↗

Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase.Semantic proximity Read ↗

ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.Semantic proximity Read ↗

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.Semantic proximity Read ↗

AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity.Semantic proximity Read ↗

A phosphatidylinositol (4,5)-bisphosphate binding site within mu2-adaptin regulates clathrin-mediated endocytosis.Semantic proximity Read ↗

ADP-ribosylation factor 6 and a functional PIX/p95-APP1 complex are required for Rac1B-mediated neurite outgrowth.Semantic proximity Read ↗

Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments.Semantic proximity Read ↗

Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation.Semantic proximity Read ↗

ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages.Semantic proximity Read ↗

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.