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Article

IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer.

The Prostate - 15 Sept 2005

Friedrichsen Danielle M, Hawley Sarah, Shu Jainfen, Humphrey Mariela, Sabacan Leah, Iwasaki Lori, Etzioni Ruth, Ostrander Elaine A, Stanford Janet L

Abstract excerpt

BACKGROUND: Insulin-like growth factor-I (IGF-I) is a potent mitogen for both normal and malignant prostate epithelial cells. The majority of circulating IGF-I is bound in a complex with IGF binding protein-3 (IGFBP-3), which in turn limits IGF-I bioavailability. Multiple studies suggest that higher IGF-I and/or lower IGFBP-3 serum levels are positively associated with prostate cancer risk. Several polymorphisms...

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PMID: 15800934
DOI: 10.1002/pros.20259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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