Article
The XRCC1 399Gln polymorphism and the frequency of p53 mutations in Taiwanese oral squamous cell carcinomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2003
Hsieh Ling-Ling, Chien Huei-Tzu, Chen I-How, Liao Chun-Ta, Wang Hung-Ming, Jung Shih-Ming, Wang Pei-Feng, Chang Joseph Tung-Chieh, Chen Min-Chi, Cheng Ann-Joy
Abstract excerpt
DNA repair gene polymorphisms have been implicated as susceptibility factors in cancer development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. The 399Gln polymorphism in the DNA repair gene XRCC1 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of cancer development. Two hundred thirty-seven...
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