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Article

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

26 Nov 2002

Abstract excerpt

We examined isolated leukemia B cells of patients with chronic lymphocytic leukemia (CLL) for expression of zeta-associated protein 70 (ZAP-70). CLL B cells that have nonmutated immunoglobulin variable region genes (V genes) expressed levels of ZAP-70 protein that were comparable to those expressed by normal blood T cells. In contrast, CLL B cells that had mutated immunoglobulin variable V genes, or that had...

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PMID: 12393534
DOI: 10.1182/blood-2002-06-1683

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