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Article

Dysregulation of Epstein-Barr Virus Infection in Hypomorphic ZAP70 Mutation.

The Journal of infectious diseases - 24 Jul 2018

Hoshino Akihiro, Takashima Takehiro, Yoshida Kenichi, Morimoto Akira, Kawahara Yuta, Yeh Tzu-Wen, Okano Tsubasa, Yamashita Motoi, Mitsuiki Noriko, Imai Kohsuke, Sakatani Takashi, Nakazawa Atsuko, Okuno Yusuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Ogawa Seishi, Kojima Seiji, Morio Tomohiro, Kanegane Hirokazu

Abstract excerpt

Background: Some patients with genetic defects develop Epstein-Barr virus (EBV)-associated lymphoproliferative disorder (LPD)/lymphoma as the main feature. Hypomophic mutations can cause different clinical and laboratory manifestations from null mutations in the same genes. Methods: We sought to describe the clinical and immunologic phenotype of a 21-month-old boy with EBV-associated LPD who was in good health...

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Source

Identifiers

PMID: 29684201
DOI: 10.1093/infdis/jiy231

Genes

ZAP70

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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