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Article

Nuclear targeting of transforming growth factor-beta-activated Smad complexes.

The Journal of biological chemistry - 3 Jun 2005

Chen Hong Bing, Rud Jonathan G, Lin Kai, Xu Lan

Abstract excerpt

Upon stimulation by the transforming growth factor beta (TGF-beta), Smad2 and Smad3 are phosphorylated at their C termini and assemble into stable heteromeric complexes with Smad4. These complexes are the functional entities that translocate into the nucleus and regulate the expression of TGF-beta target genes. Here we report that the TGF-beta-activated phospho-Smad3/Smad4 complex utilizes an importin-independent...

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Identifiers

PMID: 15799969
DOI: 10.1074/jbc.M500362200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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