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Article

Structural and Functional Characterization of the Transforming Growth Factor-β-induced Smad3/c-Jun Transcriptional Cooperativity

1 Dec 2000

Abstract excerpt

Smads are intracellular proteins that act as central effectors for transforming growth factor-beta (TGF-beta) and related proteins from the activated receptor into the nucleus, where they regulate ligand-induced gene expression. AP-1 binding sites have been functionally linked to the transcriptional activation of various genes in response to TGF-beta. Accordingly, we have previously shown that the heteromeric...

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PMID: 10995748
DOI: 10.1074/jbc.m004731200

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