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Article

Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.

Molecular and cellular biology - 1 Apr 2005

Ray Dipankar, Terao Yasuhisa, Nimbalkar Dipali, Chu Li-Hao, Donzelli Maddalena, Tsutsui Tateki, Zou Xianghong, Ghosh Asish K, Varga John, Draetta Giulio F, Kiyokawa Hiroaki

Abstract excerpt

Ubiquitin-dependent degradation of Cdc25A is a major mechanism for damage-induced S-phase checkpoint. Two ubiquitin ligases, the Skp1-cullin-beta-TrCP (SCFbeta-TrCP) complex and the anaphase-promoting complex (APCCdh1), are involved in Cdc25A degradation. Here we demonstrate that the transforming growth factor beta (TGF-beta)-Smad3 pathway promotes SCF(beta-TrCP)-mediated Cdc25A ubiquitination. Cells treated with...

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Identifiers

PMID: 15798217
DOI: 10.1128/MCB.25.8.3338-3347.2005
PMCID: PMC1069597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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