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Article

Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation.

The Journal of biological chemistry - 25 May 2007

Poncelet Anne-Christine, Schnaper H William, Tan Ruoyun, Liu Youhua, Runyan Constance E

Abstract excerpt

Signaling by transforming growth factor-beta (TGF-beta), a regulator of several biological processes, including renal fibrosis, is mediated, in part, by the Smad proteins. Tight control of Smad level and activity is critical for proper TGF-beta biological functions. Here, we have investigated the mechanisms involved in regulating Smad3 expression. In human glomerular mesangial cells, Smad3 protein levels were...

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Identifiers

PMID: 17400544
DOI: 10.1074/jbc.M701991200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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