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Article

SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.

Journal of cell science - 15 Aug 2011

Uchida Sanae, Watanabe Nobumoto, Kudo Yasusei, Yoshioka Katsuji, Matsunaga Tsukasa, Ishizaka Yukihito, Nakagama Hitoshi, Poon Randy Y C, Yamashita Katsumi

Abstract excerpt

Cdc25A, which is one of the three mammalian CDK-activating Cdc25 protein phosphatases (Cdc25A, B and C), is degraded through SCF(βTrCP)-mediated ubiquitylation following genomic insult; however, the regulation of the stability of the other two Cdc25 proteins is not well understood. Previously, we showed that Cdc25B is primarily degraded by cellular stresses that activate stress-activated MAPKs, such as Jun...

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Identifiers

PMID: 21807946
DOI: 10.1242/jcs.083931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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