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Article

Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons.

Neuron - 24 Mar 2005

Udo Hiroshi, Jin Iksung, Kim Joung-Hun, Li Hsiu-Ling, Youn Trisha, Hawkins Robert D, Kandel Eric R, Bailey Craig H

Abstract excerpt

Application of Clostridium difficile toxin B, an inhibitor of the Rho family of GTPases, at the Aplysia sensory to motor neuron synapse blocks long-term facilitation and the associated growth of new sensory neuron varicosities induced by repeated pulses of serotonin (5-HT). We have isolated cDNAs encoding Aplysia Rho, Rac, and Cdc42 and found that Rho and Rac had no effect but that overexpression in sensory...

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Identifiers

PMID: 15797550
DOI: 10.1016/j.neuron.2005.01.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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