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Article

Dual modes of membrane binding direct pore formation by Streptolysin O.

Molecular microbiology - 1 Sept 2015

Mozola Cara C, Caparon Michael G

Abstract excerpt

Effector translocation is central to the virulence of many bacterial pathogens, including Streptococcus pyogenes, which utilizes the cholesterol-dependent cytolysin Streptolysin O (SLO) to translocate the NAD(+) glycohydrolase SPN into host cells during infection. SLO's translocation activity does not require host cell membrane cholesterol or pore formation by SLO, yet SLO does form pores during infection via a...

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Identifiers

PMID: 26059530
DOI: 10.1111/mmi.13085
PMCID: PMC4692278

Genes

SPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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