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Article

Intracellular <i>Helicobacter pylori</i> in gastric epithelial progenitors

28 Mar 2005

Abstract excerpt

Helicobacter pylori is generally viewed as an extracellular pathogen. We have analyzed the tropism of H. pylori clinical isolates in a gnotobiotic transgenic mouse model of human chronic atrophic gastritis, a preneoplastic condition. These mice lack acid-producing parietal cells and have an amplified population of dividing gastric epithelial progenitors (GEPs) that express NeuAc alpha 2,3Gal beta 1,4-glycans...

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PMID: 15795379
DOI: 10.1073/pnas.0407657102

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