The impact of parietal cells on <i>Helicobacter pylori</i> tropism and host pathology: An analysis using gnotobiotic normal and transgenic mice

Abstract excerpt

Helicobacter pylori infection of the human stomach is common and typically benign, although a subset of hosts develops severe pathology. Infection occurs in an organ with distinct microenvironments characterized by pronounced differences in the composition of acid-producing parietal cells. In this study, we examine determinants of bacterial tropism to various gastric niches by using germ-free normal and...

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