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Article

Development of a Mouse Model of <i>Helicobacter pylori</i> Infection that Mimics Human Disease

17 Mar 1995

Abstract excerpt

The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology resembling human disease was observed in infections with cytotoxin-producing strains but not with noncytotoxic strains. Oral immunization with...

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PMID: 7886456
DOI: 10.1126/science.7886456

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