Article
Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions.
Biochemistry - 5 Apr 2005
Abdul-Aziz Dunia, Fisher Carl, Beglova Natalia, Blacklow Stephen C
Abstract excerpt
The LA repeats that comprise the ligand-binding domain of the LDL receptor are among the most common autonomously structured extracellular modules found in the nonredundant protein sequence database. Here, we investigate the information content of the amino acid sequence of a typical LA module by constructing sequences with alanine residues at nonconserved positions in the module. Starting with the sequence of...
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