Article
The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia.
American journal of human genetics - 1 May 2005
Pimm Jonathan, McQuillin Andrew, Thirumalai Srinivasa, Lawrence Jacob, Quested Digby, Bass Nicholas, Lamb Graham, Moorey Helen, Datta Susmita R, Kalsi Gursharan, Badacsonyi Allison, Kelly Katie, Morgan Jenny, Punukollu Bhaskar, Curtis David, Gurling Hugh
Abstract excerpt
Chromosome 5q33 is a region that has previously shown good evidence of linkage to schizophrenia, with four LOD scores >3.00 in independent linkage studies. We studied 450 unrelated white English, Irish, Welsh, and Scottish research subjects with schizophrenia and 450 ancestrally matched supernormal controls. Four adjacent markers at the 5' end of the Epsin 4 gene showed significant evidence of linkage...
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