Article
Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia.
Human molecular genetics - 15 Oct 2008
Ikeda Masashi, Hikita Takao, Taya Shinichiro, Uraguchi-Asaki Junko, Toyo-oka Kazuhito, Wynshaw-Boris Anthony, Ujike Hiroshi, Inada Toshiya, Takao Keizo, Miyakawa Tsuyoshi, Ozaki Norio, Kaibuchi Kozo, Iwata Nakao
Abstract excerpt
Schizophrenia is a complex mental disorder with a fairly high degree of heritability. Although the causes of schizophrenia remain unclear, it is now widely accepted that it is a neurodevelopmental and neurodegenerative disorder involving disconnectivity and disorder of the synapses. Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene involved in neurodevelopment, including maturation...
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