Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes.

doi:10.2337/diabetes.54.4.1185

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Article

Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes.

Diabetes - 1 Apr 2005

Bagwell Allison M, Bento Jennifer L, Mychaleckyj Josyf C, Freedman Barry I, Langefeld Carl D, Bowden Donald W

Abstract excerpt

Hepatocyte nuclear factor 4alpha (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes-linked region on chromosome 20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the general population. Previous studies have identified only a few rare coding mutations. However, recent studies suggest that single...

Topics

DNA-Binding Proteins
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Haplotypes
Hepatocyte Nuclear Factor 4
Humans
Phosphoproteins
Polymorphism, Single Nucleotide
Transcription Factors
United States
White People

Source

Open in PubMed

Identifiers

PMID: 15793260
DOI: 10.2337/diabetes.54.4.1185

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