Article
A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Diabetes - 1 Aug 2005
Weedon Michael N, Owen Katharine R, Shields Beverley, Hitman Graham, Walker Mark, McCarthy Mark I, Hattersley Andrew T, Frayling Timothy M
Abstract excerpt
HNF1alpha (TCF1) is a key transcription factor that is essential for pancreatic beta-cell development and function. Rare mutations of HNF1alpha cause maturity-onset diabetes of the young. A common variant, G319S, private to the Oji-Cree population, predisposes to type 2 diabetes, but the role of common HNF1alpha variation in European populations has not been comprehensively assessed. We determined the linkage...
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