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Article

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

Nature cell biology - 1 Dec 2013

Pan Xin, Liu Jie, Nguyen Tiffany, Liu Chengyu, Sun Junhui, Teng Yanjie, Fergusson Maria M, Rovira Ilsa I, Allen Michele, Springer Danielle A, Aponte Angel M, Gucek Marjan, Balaban Robert S, Murphy Elizabeth, Finkel Toren

Abstract excerpt

Mitochondrial calcium has been postulated to regulate a wide range of processes from bioenergetics to cell death. Here, we characterize a mouse model that lacks expression of the recently discovered mitochondrial calcium uniporter (MCU). Mitochondria derived from MCU(-/-) mice have no apparent capacity to rapidly uptake calcium. Whereas basal metabolism seems unaffected, the skeletal muscle of MCU(-/-) mice...

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Identifiers

PMID: 24212091
DOI: 10.1038/ncb2868
PMCID: PMC3852190

Genes

MCU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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