Article
BRAF and RAS mutations in human lung cancer and melanoma.
Cancer research - 1 Dec 2002
Brose Marcia S, Volpe Patricia, Feldman Michael, Kumar Madhu, Rishi Irum, Gerrero Renee, Einhorn Eugene, Herlyn Meenhard, Minna John, Nicholson Andrew, Roth Jack A, Albelda Steven M, Davies Helen, Cox Charles, Brignell Graham, Stephens Philip, Futreal P Andrew, Wooster Richard, Stratton Michael R, Weber Barbara L
Abstract excerpt
BRAF encodes a RAS-regulated kinase that mediates cell growth and malignant transformation kinase pathway activation. Recently, we have identified activating BRAF mutations in 66% of melanomas and a smaller percentage of many other human cancers. To determine whether BRAF mutations account for th...
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