Article

Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing Era

2019-11-29

Abstract excerpt

Hardy-Weinberg Equilibrium (HWE) is used to estimate the number of homozygous and heterozygous variant carriers based on its allele frequency in populations that are not evolving. Previously, deviation from HWE in large population databases were investigated to detect genotyping errors, which can result in extreme heterozygote excess (HetExc). However, HetExc might also be a sign of natural selection since recessi...

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Literature Corpus work: f6050157-39d3-59f9-b8e6-e4d9643882b8
DOI: 10.1101/859462

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