Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase.

The Journal of biological chemistry - 3 Jun 2005

Agassandian Marianna, Zhou Jiming, Tephly Linda A, Ryan Alan J, Carter A Brent, Mallampalli Rama K

Abstract excerpt

Surfactant deficiency contributes to acute lung injury and may result from the elaboration of bioactive lipids such as oxysterols. We observed that the oxysterol 22-hydroxycholesterol (22-HC) in combination with its obligate partner, 9-cis-retinoic acid (9-cis-RA), decreased surfactant phosphatidylcholine (PtdCho) synthesis by increasing phosphorylation of the regulatory enzyme CTP:phosphocholine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Signal-Regulated MAP Kinases
Share to Flavonoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Phosphatidylcholines

Share to Receptors, Steroid

Share to Sterols

Share to Surface-Active Agents

Share to Tretinoin

Source

Identifiers

PMID: 15788406
DOI: 10.1074/jbc.M412409200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase.PMID 15788406Read ↗

Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis.Semantic proximity Read ↗

Functions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cells.Semantic proximity Read ↗

Role of phosphocholine cytidylyltransferase alpha in lung development.Semantic proximity Read ↗

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein.Semantic proximity Read ↗

Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis.Semantic proximity Read ↗

Stat1-Dependent, p53-Independent Expression of p21 waf1 Modulates Oxysterol-Induced ApoptosisSemantic proximity Read ↗

Detection of a mitochondrial kinase complex that mediates PKA-MEK-ERK-dependent phosphorylation of mitochondrial proteins involved in the regulation of steroid biosynthesis.Semantic proximity Read ↗

Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1.Semantic proximity Read ↗

Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1.Semantic proximity Read ↗

The rate-limiting enzyme in phosphatidylcholine synthesis regulates proliferation of the nucleoplasmic reticulum.Semantic proximity Read ↗

Role of CBP/p300 and SRC-1 in Transcriptional Regulation of the Pulmonary Surfactant Protein-A (SP-A) Gene by Thyroid Transcription Factor-1 (TTF-1)Semantic proximity Read ↗

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.