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Article

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.

Journal of lipid research - 1 Mar 2014

Luu Winnie, Zerenturk Eser J, Kristiana Ika, Bucknall Martin P, Sharpe Laura J, Brown Andrew J

Abstract excerpt

The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis, 3β-hydroxysterol Δ24-reductase (DHCR24). Many factors are known to regulate DHCR24 transcriptionally, but little is known about its posttranslational regulation. We...

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Identifiers

PMID: 24363437
DOI: 10.1194/jlr.M043257
PMCID: PMC3934726

Genes

DHCR24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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